Molecular biology

• Upstream and downstream (DNA), determining relative positions on DNA

• Upstream and downstream (transduction), determining temporal and mechanistic order of cellular and molecular events of signal transduction

• Upstream (oil industry)

• Upstream (bioprocess)

Companies

• Upstream Marketing and Communications Inc.

Media

• Upstream (film), a 1927 film directed by John Ford

• Upstream (newspaper), a weekly, independent trade newspaper covering the global oil and gas industry.

Computer science

• Upstream (networking)

• Upstream (software development)

• Upstream server