• Southworth, Washington - unincorporated community on Puget Sound in Kitsap County, Washington.

• Point Southworth - on Kitsap Peninsula on the western side of the northern entrance to Colvos Passage in Puget Sound.

People

• E. D. E. N. Southworth (1819 – 1899) - American writer.

• Billy Southworth (1893 - 1969) - American baseball player and manager.

• John Southworth - Canadian pop singer-songwriter.

• Daniel Southworth (1974 - ) - Actor.

• Bobby Southworth (1969 - ) - American mixed martial arts fighter.

• Laura Simonds Southworth - a book illustrator.

• Helen Southworth (1956 - ) - a politician in the United Kingdom.

• George Clark Southworth (1890 - 1972) - American radio engineer discoverer of waveguides.

• Albert Southworth (1811–94) - co-propietor of Southworth & Hawes studio.

• John Southworth (1592 - 1654) - English Catholic martyr.

• Dorothy Fay Southworth (1915 – 2003)) - American actress born with the name of Dorothy Fay.

• Azariah Southworth (1987 - ) - Music producer and broadcaster.

• Bill Southworth (1946 - ) - Entrepreneur, electronic music pioneer, filmmaker.

• Christine Southworth (1978 - ) - Composer and Music Producer, founder of MIT's Ensemble Robot.

Fictional characters

• Eleanor "Miss Ellie" Southworth Ewing Farlow - a character in the American television series Dallas, played by Barbara Bel Geddes and also by Donna Reed.

Others

• Southworth & Hawes - an early photographic firm in Boston.