Run is one of the smallest islands of the Banda Islands which are a part of Indonesia. It is about 3 km long and less than 1 km wide.

In earlier times Run was of considerable economic importance due to the value of the spices nutmeg and mace which are obtained from the nutmeg tree (Myristica fragans), at that time only growing on the Banda Islands. During the history of the spice trade sailors of the British East India Company of the second expedition of James Lancaster, John Davis and John Middleton who stayed in Bantam on Java first reached the Island in 1603 and developed good contacts with the inhabitants.
On December 25th, 1616 , Captain Nathaniel Courthope reached Run to defend it against claims of the Dutch East India Company. A contract with the inhabitants was signed accepting the English King as sovereign of the island. After four years of siege by the Dutch and the murder of Nathaniel Courthope in an ambush in 1620, the English and their local allies departed without a struggle.

According to the Treaty of Westminster ending the First Anglo-Dutch War of 1652–1654 Run should have been returned to England. The first attempt in 1660 failed due to formal constraints by the Dutch; after the second in 1665 the English traders were expelled in the same year and the Dutch destroyed the nutmeg trees.
After the second Anglo-Dutch War of 1665–1667 England and the United Provinces of the Netherlands agreed in the Treaty of Breda to the status quo: The English kept the island of Manhattan which the Duke of York (the future James II, brother of Charles II), had occupied illegally in 1664 and renamed from New Amsterdam to New York and Run was officially abandoned to the Dutch. The Dutch monopoly on nutmeg and mace was destroyed by the transfer of nutmeg trees to Ceylon, Singapore and other British colonies in 1817 after the capture of the main island, Bandalontor, in 1810 by Captain Cole leading to the decline of the Dutch supremacy in the spice trade. There are, however, still nutmeg trees growing on Run today.