Kathryn "Kathy" Keeton (b. 1939, South Africa – September 19, 1997, New York, New York) was a magazine publisher along with her partner, and later husband, Penthouse publisher Bob Guccione. Her title was President/COO of General Media Communications, Inc.
She founded the magazines Viva (1973);
OMNI (1979); and Longevity (1989). She also published two books, Woman of Tomorrow (1986) and Longevity (1992).

After her diagnosis with breast cancer, Keeton treated herself with hydrazine sulfate, after reading about it in OMNI, one of her own publications. She claimed that she had ridden or shrunken almost all of the tumors and extended her life by several years, after being given a dire initial prognosis of only six weeks to live by her doctors.

Keeton died of complications during surgery for an intestinal obstruction, aged 58, in New York City.