The East-West Highway is a long-proposed east-west highway corridor in northern New England, intended to link remote northern communities in Maine, New Hampshire and Vermont with markets in the Maritimes, Québec and upper New York State.

Well-worn Yankee truisms like "You can't get there from here" have their basis in the difficulties east-west travel poses in much of northern New England. Natural barriers like the White Mountains and significant distances to population centers in southern New England have left the region underdeveloped economically. (At present, Interstate 90 in Massachusetts is the northernmost complete east-west freeway in New England.)

Proposals for an east-west highway date back to the 1940s.

In the early 1970s, all three northern New England states and New York proposed two new Interstate Highway corridors: one from Albany, New York, to Portsmouth, New Hampshire, and another from Glens Falls, New York, to Calais, Maine. The southerly corridor incorporated the route of the current New Hampshire Route 101 expressway, while the northerly corridor (designated as Interstate 92) traced U.S. Route 4 through Vermont and New Hampshire. The Federal Highway Administration ultimately did not approve the plan.

Current backers of the highway propose an east-west axis through northern and central Maine.

One portion of the new highway would run from Interstate 395 in Brewer, Maine, to the Canada-United States border near Calais, with a direct link to New Brunswick Route 1 - a major transportation corridor serving the Maritimes.

A second would travel northwest from Interstate 95 near Waterville, Maine, to the Canada-United States border at Coburn Gore, with a connection to a proposed extension of Quebec Autoroute 10 toward Montreal.

A third would travel due west from Interstate 95 near Waterville, following the U.S. Route 2 corridor through Maine, New Hampshire, Vermont and upper New York state.

Maine Senator Olympia Snowe said in 2004 that the region is disadvantaged by the fact that it was the only region in the United States for which a federal High Priority Corridor was not designated in the 1991 Intermodal Surface Transportation Efficiency Act.