The 5th millennium BC saw the spread of agriculture from the Near East throughout southern and central Europe.

Urban cultures in Mesopotamia and Anatolia flourish, developing the wheel. Copper ornaments become more common, marking the Chalcolithic. Animal husbandry spreads throughout Eurasia, reaching China. World population grows slightly throughout the millennium, maybe from 5 to 7 million people.

Cultures

• Badari culture on the Nile (c. 4400–4000 BC)

• Comb Ceramic culture (also endured the 6th, 4th)

• Maykop culture

• Merimde culture on the Nile (c. 4570–4250 BC)

• Predynastic Egypt

• Proto-Austronesian culture is based on the south coast of China. They combine extensive maritime technology, fishing with hooks and nets and gardening. (c. 5000 BC)

• Samara culture

• Sredny Stog culture

• Ubaid culture

• Vinča culture (also endured the 6th, 4th, and 3rd millennia)

Events

• 5000–4500 BC: Għar Dalam phase of Neolithic farmers on Malta, possibly immigrant farmers from the Agrigento region of Sicily.

• 5000–4000 BC: Bowl, from Banpo, near Xi'an, Shaanxi, is made. Neolithic period. Yangshao culture. It is now kept at Banpo Museum.

• 5000–2000 BC: Neolithic period in China.

• 4900–4600 BC: Arrangements of circular ditches are built in Central Europe.

• 4800 BC: Dimini culture replaces the Sesklo culture in Thessaly (4800–4000 BC)

• c. 4500 BC: Settlement of Chirokitia dates from this period.

• c. 4500 BC: Ending of Neolithic IA (the Aceramic) in Cyprus

• c. 4350 BC: Kikai Caldera forms in a massive VEI7 eruption.

• 4300 BC: Theta Boötis became the nearest visible star to the celestial north pole. It remained the closest until 3942 BC when it was replaced by Thuban.

• c. 4250–3750 BC: Menhir alignments at Menec, Carnac, France are made.

• 4200 BC: Date of Mesolithic examples of Naalebinding found in Denmark, marking spread of technology to Northern Europe. (Bender 1990)

• 4100–3500 BC: New wave of immigration to Malta from Sicily leads to the Żebbuġ and Mġarr phases, and to the Ġgantija phase of temple builders.

Inventions, discoveries, introductions

• Rice is cultivated in Southeast Asia. Later it is introduced in Ganges Valley (c. 5000 BC).

• Farming reaches Atlantic coast of Europe from Ancient Near East (c. 5000 BC).

• Maize is cultivated in Mexico (c. 5000 BC).Roberts, J: "History of the World." Penguin, 1994.

• Writing systems, such as ideographic Vinca script, Tartaria tablets (c. 5000 BC)

• c. 5000 BC – Metallurgy appears.

• c. 5000 BC - Agriculture starts in Ancient Japan.

• Plough is introduced in Europe (c. 4500 BC)

• Copper pins dating to 4000 BC found in Egypt.

• Water Buffalo are domesticated in China

• Beer brewing is developed.

• Wheel is developed in Mesopotamia and India

Environmental changes

• 5000–4900 BC: The Older Peron transgression, a warm period that would dominate the 5th millennium, begins in this period.

Calendars and chronology

• 4713 BC: The epoch (origin) of the Julian Period described by Joseph Justus Scaliger occurred on January 1, the astronomical Julian day number zero.

• 4121 BC: Eduard Meyer's date for the creation of the Egyptian calendar, based on his calculations of the Sothic cycle.

• 4004 BC—According to the chronology created by James Ussher based on the Old Testament of the Bible, this is when the universe is created at nightfall preceding October 23.

Fiction

• 4372 BC: Setting for the Year the Horses Came by Mary Mackey (Earthsong trilogy book 1).

• 4368 BC: Setting for the Horses at the Gate by Mary Mackey (Earthsong trilogy book 2)

• 4004 BC: Setting for the year the fictional immortal Natla from the Tomb Raider game series was born in Atlantis.