Events

• January 25 – Alfonso II becomes King of Naples.

• May 3 – Christopher Columbus first spots Jamaica.

• May 31 – First Battle of Acentejo: Natives of the island of Tenerife, known as Guanches, defeat the invading Spanish forces.

• June 7 – Treaty of Tordesillas: Spain and Portugal divide the New World between themselves.

• October 22 – Ludovico Sforza becomes Duke of Milan, and starts a chain of events that leads to the First Italian War.

Undated

• Amda Seyon II succeeds his father Eskender as Emperor of Ethiopia.

• Na'od succeeds his nephew Amda Seyon II as Emperor of Ethiopia.

• Aztec forces conquer and sack Mitla.

• Italy is invaded by Charles VIII of France.

Births

• February 2 – Bona Sforza, queen of Sigismund I of Poland (d. 1557)

• April 9 – Francois Rabelais, French Renaissance writer (d. 1553)

• April 20 – Johannes Agricola, German Protestant reformer (d. 1566)

• May 24 – Pontormo, Italian painter (d. 1557)

• September 5 – Hans Sachs, German Meistersinger (d. 1576)

• September 12 – King Francis I of France (d. 1547)

• November 6 – Suleiman the Magnificent, Ottoman Sultan (d. 1566)

• date unknown

• *Saitō Dōsan, Japanese warlord (d. 1556)

• *John Sutton, 3rd Baron Dudley (d. 1554)

• *Juan Ginés de Sepúlveda, Spanish philosopher and theologian (d. 1573)

• *Ambrosius Holbein, German painter (d. 1519)

• *Alonso Álvarez de Pineda, Spanish explorer and cartographer (d. 1519)

• *Hans Tausen, Danish religious reformer (d. 1561)

• *Qiu Ying, Chinese painter (d. 1552)

• *William Tyndale, English reformer and martyr (d. 1536)

• *Christina Gyllenstierna, Swedish national heroine (d.1559)

Deaths

• January 11 – Domenico Ghirlandaio, Italian artist (b. 1449)

• January 25 – King Ferdinand I of Naples (b. 1423)

• August 1 – Giovanni Santi, artist and father of Raphael (b. c. 1435)

• August 11 – Hans Memling, Flemish painter (b. c. 1430)

• September 24 – Poliziano, Italian humanist (b. 1454)

• October 26 – Amda Seyon II, Emperor of Ethiopia (b. c. 1487)

• November 8 – Melozzo da Forlì, painter (b. c. 1438)

• November 17 – Giovanni Pico della Mirandola, Italian humanist (b. 1463)

• December 20 – Matteo Maria Boiardo, Italian poet (b. c. 1434)

• date unknown

• *Eskender, Emperor of Ethiopia (b. 1472)